Alzheimer's Disease (drugs that may help - Viagra, Leqembi, more)

Viagra Lowers the Risk of Alzheimer’s by Almost 70%, Study Says

ByThomas Kissel
December 11, 2022

New research published recently suggests that Pfizer’s erectile dysfunction drug Viagra can decrease the risk of developing Alzheimer’s disease by up to 69 percent.

The research, which was published in Nature, found that the medication has a direct effect on brain health and significantly reduces the toxic proteins that can cause dementia.

The study’s findings are so promising that the drug may someday be used to counter dementia. A new team of experts is preparing to conduct another study that builds on this data but tests the generic version of Viagra, sildenafil, in patients suffering from early Alzheimer’s.

Read the rest here:

That's a bit hard to take.

I trust research on Pfizer’s drugs. Especially if it is published in Nature mag.

A local guy died from a Viagra overdose. It doesn't mix well with heart medication. He was married and died in a motel with his girlfriend. She called an ambulance but left before it came. Still its a small town and everyone heard the story. It was one of the best attended local funerals on record.

Schwing... Careful some of you all might get a little too excited.

The study is a statistical analysis of insurance claims, but the abstract also says:

... We also found that sildenafil increases neurite growth and decreases phospho-tau expression in neuron models derived from induced pluripotent stem cells from patients with AD, supporting mechanistically its potential beneficial effect in AD. The association between sildenafil use and decreased incidence of AD does not establish causality, which will require a randomized controlled trial.

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Seems like the drug affects stem cells in lab, so there appears to be a mechanism for the mitigation that isn't correlated with lowering blood pressure (or endorphins from engaging in sex). Interesting.

1m 30s
you have to watch for the 'nuance'....

If you got a 4 hr woody at 70 years old you probably dont care about anything else.

Cigarlover said:

If you got a 4 hr woody at 70 years old you probably dont care about anything else.

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You know I have a story I posted this on GIM a long time ago I think

I used to get a lot of chest pain guys in their 70s. We ran stress tests on them. Part of the test was prepping them. We shaved and cleaned their chest and hooked them up to electrodes. My weekend work partner was a attractive young lesbian. She was delightful to work with and the male patients loved her. She like men too, just not the penis part. One of our patients was a 72 year old male. We each took a side and started to go to work. He stopped us and said. This is embarrassing but I thought you ladies needed to know that I get spontaneous erections when women touch me. There is nothing I can do about it so I'm apologizing ahead of time. To make matters worse the guy had on the hospital PJ bottoms with the hole in the top and indeed things were beginning to poke out the hole. My coworker looked sort of mortified then told him not to worry. She took tape and strapped that thing down. They both look relieved and the test went on without event. My male coworkers were not concerned about his peek a boo penis, They were just impressed at 72 years old he had this problem.

Avalon said:

She like men too, just not the penis part.

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Her loss... I mean nothing wrong with lezzies... we're similar in that respect, I'll eat what they eat.

Avalon said:

at 72 years old he had this problem.

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This is 'a problem' ??

Around here there are Alzheimer's facilities. They used to separate those couples 'caught in the act' who found themselves 'attracted' to each other at times.

They quit that practice as I think they figured out that they actually were old enough to make those 'decisions' for themselves.

Avalon said:

A local guy died from a Viagra overdose. It doesn't mix well with heart medication. He was married and died in a motel with his girlfriend. She called an ambulance but left before it came. Still its a small town and everyone heard the story. It was one of the best attended local funerals on record.

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Whoops.

Poor widow, a hell of a story to live down.

If you have to register to read the article - it's free and quick.

LOS ANGELES, July 6 (Reuters) - Eisai (4523.T) and Biogen's (BIIB.O) Leqembi won a coveted standard approval nod from the U.S. Food and Drug Administration on Thursday, the first Alzheimer's treatment to achieve that goal, clearing the way for wider insurance coverage of the drug.

The FDA decision marks a new milestone for a fatal disease that has eluded drugmakers' efforts for decades. Trial data showed that the treatment slows progression of the brain-wasting disease by 27% for patients in the earliest stages of Alzheimer's.

Libertas said:

A local guy died from a Viagra overdose. It doesn't mix well with heart medication. He was married and died in a motel with his girlfriend. She called an ambulance but left before it came. Still its a small town and everyone heard the story. It was one of the best attended local funerals on record.

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Heck, I take a Viagra every night.




Keeps me from rolling out of bed in the middle of the night.

Not a drug but a test that may help head it off.

Neurosurgeon pioneers Alzheimer's, addiction treatments using ultrasound | 60 Minutes​

Jan 15, 2024
American neurosurgeon Ali Rezai is pioneering ways to try to help people with drug addiction and with Alzheimer's disease. One experiment focuses beams of ultrasound on the brain.

26:37