Since mutated flu strains are in the news again:
http://news.yahoo.com/deeply-concerned-mutant-bird-flu-041057122.html
I thought it would be appropriate to share this bit of research I found back when H1N1 was all the rage:
http://www.cytokinestorm.com/
Looks like Oil of Oregano might be helpful:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2233768
http://www.prweb.com/releases/2006/05/prweb383231.htm
The World Health Organization (WHO) said it was "deeply concerned" about research into whether the H5N1 flu virus could be made more transmissible between humans after mutant strains were produced in labs.
Two separate research teams -- one in the Netherlands and the other in the United States -- have found ways to alter the H5N1 avian influenza so it could pass easily between mammals.
Two top scientific journals said on Tuesday they were mulling whether to publish full details on how Dutch scientists mutated the H5N1 flu virus in order for it to pass from one mammal to another.
Scientists fear H5N1 will mutate into a form readily transmissible between humans, with the potential to cause millions of deaths.
...
http://news.yahoo.com/deeply-concerned-mutant-bird-flu-041057122.html
I thought it would be appropriate to share this bit of research I found back when H1N1 was all the rage:
A cytokine storm is the systemic expression of a healthy and vigorous immune system resulting in the release of more than 150 inflammatory mediators (cytokines, oxygen free radicals, and coagulation factors). Both pro-inflammatory cytokines (such as Tumor Necrosis Factor-alpha, InterLeukin-1, and InterLeukin-6) and anti-inflammatory cytokines (such as interleukin 10, and interleukin 1 receptor antagonist) are elevated in the serum, and the fierce and often lethal interplay of these cytokines is referred to as a "Cytokine Storm". The primary contributors to the cytokine storm are TNF-a (Tumor Necrosis Factor-alpha) and IL-6 (Interleukin-6). ...
http://www.cytokinestorm.com/
Looks like Oil of Oregano might be helpful:
We examined the anti-inflammatory effects of the combination of thyme and oregano essential oil dietary administered at three concentrations (0.4% thyme and 0.2% oregano oils; 0.2% thyme and 0.1% oregano oils; 0.1% thyme and 0.05% oregano oils) on mice with TNBS-induced colitis. Treatment of colitic animals with the essential oils decreased the mRNA levels of pro-inflammatory cytokines IL-1, IL-6, GM-CSF, and TNF, especially after application of the medium dose. The medium dose of the essential oils significantly lowered the amount of IL-1 and IL-6 proteins too. Moreover, administration of the medium dose decreased the mortality rate, accelerated the body weight gain recovery, and reduced the macroscopic damage of the colonic tissue. Our results indicate that combined treatment with appropriate concentrations of thyme and oregano essential oils can reduce the production of proinflammatory cytokines, and thereby attenuate TNBS-induced colitis in mice.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2233768
(PRWEB) May 10, 2006 -- A Biology teacher from Australia, named Stephen Jones, has done extensive research into the bird flu and compiled a list of natural foods that are effective against the Bird Flu virus and listed others that are detrimental.
The list may come as a surprise to many people since foods such as spirulina and echinacea are listed as detrimental. This strange occurrence is largely due to the fact that the virus is immune to 2 cytokines that the body produces (TNF-a and IL-6). Cytokines are compounds produced by the body’s immune system that attack and remove foreign bodies. The problem is that when a foreign body is immune to certain cytokines, the body sees that its immune response is not working and tries even harder, which can lead to what is called a cytokine storm, where the body becomes flooded with these compounds and they eventually destroy the body itself. Foods such as Echinacea actually stimulate the production of these specific cytokines; hence consuming it is not a good idea if one suspects they may have the virus.
During the 1918 Spanish Flu (similar to Bird Flu) many healthy young people died from cytokine storms due to their immune systems overreacting (see http://www.bird-flu-influenza.com/what-are-the-symptoms-bird-flu.htm ). Consuming foods which suppress the production of cytokines TNF-a and IL-6 and enhance the production of the ones that actually are effective against the virus will aid the patient greatly.
Other foods that create mucous in the respiratory tract, such as bananas, are also listed as detrimental due to the fact that the predominant breeding ground of the virus is the respiratory tract and another way in which a patient may suffer is due to the bodies over production of mucous in this area.
The table has been reprinted below from the website with kind permission from the Author:
Folk Medicines and Herbs to use and avoid with Bird Flu
Below is a list of foods that are said to contain substances that are natural antivirals, immune boosters or they decrease cytokines TNF-a and IL-6.
Alternative medications that are most likely to help us during a severe pandemic:
Garlic (allicin) - Very effective antiviral. Best if fresh (raw) and crushed. Must be consumed within 1 hour of crushing. Dosage is initially 2 to 3 cloves per day but later reduce until no body odour occurs. No toxic effects noted. (Pubmed PMID 9049657)
Vitamin C - Boosts the immune system and is an antiviral by blocking the enzyme neuraminadase. Viruses need neuraminadase to reproduce. There are anecdotal stories of people taking large amounts of Vitamin C (children ½) surviving the Spanish Flu. Research shows that it may reduce the production of cytokines TNF-a and IL-6. A study on 470 people involved giving the test group 1000 mg hourly for 6 hours and then 1000 mg 3 times daily after reporting flu symptoms. Symptoms decreased by 85%. (Pubmed PMID 10543583, 634178, 16169205, 12876306)
Green Tea (possible Tamiflu/Relenza alternative)- Very effective antiviral. Also decreases the production of the cytokine (catechins) TNF-a. Inhibits neuraminidase. May have antiviral activity that is equal to other antivirals such as Tamiflu ( Pubmed PMID 16137775 )
St Johns Wort (Hypericum) - Very effective antiviral. Also decreases the production of the cytokine IL-6. Hypericum is an extract from St John’s Wort. There have been some very successful field trials in commercial flocks infected with H5N1 in Vietnam. (Pubmed PMID 7857513, 11518071, 11362353, 7857513, 11518071)
Vitamin E - Immune booster. Also decreases the production of the cytokine TNF-a. (Pubmed PMID 155882360, 10929076) Experiments involved using mice. Very suitable for immune compromised people, especially the elderly. Effects enhanced when taken with Vitamin C.
Apple Juice - Antiviral. Fresh apple juice including the pulp and skin has greater antiviral activity than heated commercial apple juice. More research is needed. Effectiveness on H5N1 is unknown (Pubmed PMID 32832, 12452634)
Resveratrol - Antiviral. In addition to inhibiting neuraminidase, Resveratrol also sends a message to cells to stop manufacturing viruses. This is a proven antiviral found naturally in red wine, peanuts, mulberries, Japanese Knotwood root (richest source), raisins and red grapes.
Resveratrol supplements are relatively inexpensive, are more stable than wine and is available in liquid form for absorption in the mouth. No toxic effects noted. (Pubmed PMID 1583880, 12817628, 15985724)
Scuttellaria (Skullcap)- Antiviral. A herb used as a tea. It has no side effects and is also a mild tranquilliser. Research suggests neuraminidase, which is a substance needed by the H5N1 Bird Flu virus to reproduce, may be inhibited.
Cranberry Juice - Early research shows that it may be an antiviral, making viruses less able to invade or multiply. Effectiveness on H5N1 is unknown (Pubmed PMID15781126)
Cat’s Claw (Uncaria tomentosa)- Decreases the production of the cytokine TNF-a. Also boosts immune system. The number of white blood cells was significantly increased during treatment. No toxicity was noted.
(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed) Active constituents can be found in the leaves, bark, vine, and roots. Water extraction from bark used.
Children and pregnant women are to avoid. Has a potentially damaging effect on the DNA of proliferating cells (cancers, foetuses, growing children)
Curcumin (Tumeric Spice) - Decreases the production of the cytokine TNF-a. This is the yellow compound in turmeric spice. Research shows that this may be very good for preventing a cytokine storm although this is not proven (www.pdrhealth.com/drug_info/cur_0087), (enzy.com/abstracts/display1961)
Must be taken with food or gastritis or peptic ulcers may occur. Pregnant women and feeding mothers should avoid this. The medicinal properties of curcurnin cannot be utilised when used alone due to rapid metabolism in the liver and intestinal wall. When combined with Piperine found in black pepper the absorption is increased with no adverse effects.(http://www.pdrhealth.com/drug_info/pip_0322)
Obtainable from health stores in tablets, liquid, capsules already combined with piperine. Dosage is 500mg to 4000mg daily.
Astragalus root (Astragali Radix) - Boosts immune system (Pubmed PMID15588652)
Tea tree Steam Inhalation - Reduces the cytokine TNF-a. Add 2 drops of tea tree oil in a bowl of steaming water. Cover head with a towel and inhale for 5 to 10 minutes. Relieves congestion and fights infection. Its effectiveness is unknown. (Pubmed PMID 11131302)
The following substances may be best to avoid during a H5N1 pandemic
Elderberry juice (Sambucal) - AVOID - Increases production of cytokines TNF-a and IL-6. This substance is very effective against the common flu but may not be desirable for the H5N1 Bird Flu virus. Increases in these cytokines may trigger a lethal cytokine storm. (Isr Med Journal2002 Nov;4:944-6)
Micro Algae (Chlorella and Spirulina) - AVOID - Increases production of cytokine TNF-a (Pubmed PMID 11731916)
Honey - AVOID - Increases production of cytokines TNF-a and IL-6 (Pubmed PMID12824009)
Chocolate - AVOID - Increases production of cytokines TNF-a and IL-6 (Pubmed PMID 12885154, PMID 10917928)
Echinacea - AVOID - Increases production of cytokines TNF-a and IL-6. Although it is often used for normal flu, research shows that it may increase the chance of cytokine storms for H5N1 (Pubmed PMID 15556647, 9568541)
Kimchi - AVOID - Increases production of cytokines TNF-a and IL-6 (Pubmed PMID15630182)
Dairy products & Bananas - AVOID - These foods increase mucous production.
http://www.prweb.com/releases/2006/05/prweb383231.htm
but the two above are worth a mention.
